Newbie inquiry: Does USB booting ignore HDD’s ESP/EFI ?

[mozbius 1]

When booting from a USB key are the Kexts + configs in the hard disk Clover EFI ignored?
(I am asking so to know how to make safe changes. Last time I applied a DSDT.aml file OS X wouldn't boot anymore which forced me to reinstall OS X).

[MaLd0n 1,000,896]

yes

stay with one good usb bootable and u can test some things without problems, if fail just use usb

[mozbius 1]

Thank you. 👍